R&D
Hurim R&D Center was established in 2006.
With over 14 years of experience researching adult stem cells, we have figured out the adult stem cells’ bio-characteristics for applying to various therapies through extensive work on adult stem cells.
We will continue our work until the commercialization of stem cell therapies to overcome incurable diseases.
The R&D center is formed by merging three research teams
R&D TeamⅠ
Stem cell isolation, culture, characteristics analysis
and comparative study
R&D TeamⅡ
Research on technology of future resources
by utilizing cryopreservation of stem cells
R&D TeamⅢ
GLP test & analysis on CTP(Hepa,Derma)
and co-work with other institute
Strengths of Our R&D Center
01
Possess the technology
of collecting stem cells from various human tissue and produce cell lines.
02
Accurate quality
control system
of cell management
03
Advanced technology
of cell cryopreservation
04
Co-research with medical
institutions on therapeutics of
various diseases
Domestic & Overseas Patents
Domestic patents (Registered)▼
| 10-0683198 | A process for differentiating neural progenitor cell to a dopaminergic neural cell and a culture medium therefor |
|---|---|
| 10-0683199 | A process for differentiating neural progenitor cell to a cholinergic neural cell and a culture medium therefor |
| 10-0779499 | Micro Pipette |
| 10-0801963 | Pipette for displaying volume of inspiration and exhaustion about a sample liquid |
| 10-0803576 | A composition for transplant comprising adipose stem cells or adipocytes |
| 10-0883581 | Method of differentiation of facial adipose- or umbilical cord-derived stem cells into hepatocytes and culture fluid therefore |
| 10-0895324 | Method of differentiation of facial adipose- or umbilical cord-derived stem cells into hepatocytes and culture fluid therefore |
| 10-0956267 | A semi-floating composition for transplant comprising elastin as a stabilizing agent |
| 10-0800400 | Gene related with differtiation of human stem cell lines |
| 10-0807618 | Micro-array kit for detecting the differentiation of human stem cell lines |
| 10-1137964 | SYRINGE FOR ADIPOSE TISSUE TRANSPLANT AND APPARATUS FOR DISTRIBUTING ADIPOSE TISSUE HAVING THE SAME |
| 10-1316573 | System and unit for extracting regenerative cells |
| 10-1269906 | System and unit for extracting regenerative cells |
| 10-1316574 | Multiway valve and System for extracting regenerative cells using the same |
| 10-1263820 | Device for extracting regenerative cells |
| 10-1263821 | Multiway valve and System for extracting regenerative cells using the same |
| 10-1251217 | Method for the transdifferentiation of mesenchymal stem cells into endodermal cell |
| 10-1121154 | A composition for transplant comprising adipose stem cells or adipocytes |
| 10-1316575 | Peristaltic pump and System for extracting regenerative cells using the same |
| 10-1144151 | Method for Isolation of melanocyte stem cells from stem cells of hair follicle |
| 10-1266943 | A Method for Increasing The Number of Melanocytes |
| 10-1315204 | Valve for tube |
| 10-1357160 | System and method for extracting regenerative cells |
| 10-1466923 | Device and system for extracting regenerative cells and method for extracting regenerative cells using the same |
| 10-1679671 | SYSTEM FOR EXTRACTING REGENERATIVE CELLS |
| 10-2024740 | Cryopreservation medium for mesenchymal stem cells and cryopreservation method for mesenchymal stem cells using the same |
| 10-2024742 | Cryopreservation medium for hematopoietic stem cells and cryopreservation method for hematopoietic stem cells using the same |
Domestic patents (Applied)▼
| 10-2012-0040731 | Process for preparing umbilical cord-derived mesenchymal stem cells |
|---|---|
| 10-2015-0707815 | Pharmaceutical formulation for treating vitiligo |
| 10-2016-0045633 | SYSTEM FOR EXTRACTING REGENERATIVE CELLS |
Overseas patents (Registered)▼
| Singapore-158192 | Composition for transplant comprising adipose stem cells or adipocytes |
|---|---|
| China-ZL 20108005953.6 | System and unit for extracting regenerative cells |
| Japan-5923466 | System and unit for extracting regenerative cells |
| The United States-9,388,377 | System and unit for extracting regenerative cells |
| China-ZL 201480016369.X | Device for extracting regenerative cells, system for extracting regenerative cells, and method for extracting regenerative cells using same |
| Thailand-1201001975 | System and unit for extracting regenerative cells |
Scientific Outcomes
on Isolation▼
| The 5th Biannual Meeting of Pacific Rim Society for Fertility and Sterility | Human adipose tissue-derived stem cells have characteristics of multipotent stem cells |
|---|---|
| The 5th Biannual Meeting of Pacific Rim Society for Fertility and Sterility | Human cord serum as a fetal bovine serum substitute for the culture of human amnion-derived stem cells |
| The 23rd Annual Meeting of Korean Society of Developmental Biology | Preliminary study of human adipose tissue-derived stem cells (ADSCs): Characterization of ADSCs according to an age bracket of consent volunteers |
| The 5th International Federation of Adipose Therapeutic and Science | Patterns of gene expression related to the stemness and senescence in long-termed adipose-derived stem cells |
| The 9th International Society for Stem Cell Research | Comparison of expansion and differentiation ability of mesenchymal stem cells from the different tissue sources |
| The 17th International Society for Cell Therapy | Proliferation and characterization of human umbilical cord derived stromal progenitor cells under culture condition |
| 2010 KSBMB annual meeting | Evaluation of isolation and proliferation methods for stem cells from human umbilical cord |
| The 9th International Society for Stem Cell Research | Comparative analysis of gene expression and fibroblast colony-forming abilities of human adipose- or umbilical cord-derived progenitor cells |
| The 23rd Annual Meeting of the Korean Society for Molecular and Cellular Biology | Differential gene expression depending on cultivation period of umbilical cord-derived mesenchymal stem cells |
| The 3rd International Conference of Society of Biological Engineering | Preparation of homogeneous progenitor population from human umbilical cord tissue using gene expression profiling |
| 2013 KSBB annual meeting | Characterization of umbilical cord derived mesenchymal stem cells (hUC-MSCs) depending on their isolation methods |
| The 11th International Society for Stem Cell Research | Gene expression profiling of human umbilical cord derived mesenchymal stem cells depending on passage under modified MSC culture medium |
on Culture and Proliferation▼
| The 12th Annual Meeting, International Stem Cell Therapy | Differentiation abilities of stem like cells derived from human fat tissues is not dependent on the time of cryopreservation |
|---|---|
| 2006 KSBB Spring Meeting | Effects of serum sources on differentiation abilities in adult stem cells |
| The 5th Biannual Meeting of Pacific Rim Society for Fertility and Sterility | In vitro differentiation of human adipose tissue-derived stem cells into hepatocyte-like cells |
| The 5th Biannual Meeting of Pacific Rim Society for Fertility and Sterility | In vitro differentiation of human adipose tissue-derived stem cells into insulin producing cells |
| The 4th Annual Meeting International Fat Applied Technology Society | Consideration of the conventional lineage specific markers for differentiation potential of human adipose tissue-derived stem cells |
| The 14th International Society for Cell Therapy | Consideration point for differentiation of human adipose tissue-derived stem cells into mature adipocytes |
| The 5th International Federation of Adipose Therapeutic and Science | The characterization of islets formed during adipocyte differentiation of human adipose tissue-derived stem cells |
| The 7th International Federation of Adipose Therapeutic and Science | Differential induction for in vitro adipogenesis bioassay using human adipose-derived stem cells |
| The 7th International Federation of Adipose Therapeutic and Science | Comparison of osteogenesis ability in vitro between adipose-derived stem cells and progenitor cells isolated from bone-related tissues |
| The 17th International Society for Cell Therapy | Enhancement of myogenic differentiation of human adipose tissue derived stromal cells in vitro |
on Cryopreservation and Storage▼
| 2006 KSBB Spring Meeting | Evaluation of modified processing and cryopreservation method in umbilical cord blood derived nucleated cells |
|---|---|
| The 44th Annual Meeting of the Society for Cryobiology | A preliminary study for cryopreservation components in survival and proliferation of human adipose derived stem cells |
| The 16th International Society for Cell Therapy | The effect of antifreeze proteins on adipose derived stem cells during cryopreservation |
| 2010 KSBMB annual meeting | A preliminary study for optimal storage of human dental pulp derived mesenchymal stem cells |
| 2011 KSBB Fall Meeting | Study of the substitution for xenogenic component in the cryopreservation solution of human adipose-derived progenitor cells |
| 2011 Cellular Programs and Reprogra -mming Cold Spring Harbor Asia Meeting | Preliminary study to develop the cryopreservation methods for safe application of adipose derived stem cells |
| The 3rd International Conference of Society of Biological Engineering | Characterization of thawed human hematopoietic and/or mesenchymal stem cells using colony forming unit assay |
| The 11th International Society for Stem Cell Research | Beneficial Effect of pan-caspase inhibitor for Cryopreservation of Human Umbilical Cord Derived Mesenchymal Stem Cells (hUC-MSCs) |
| The 32th Annual Meeting of Korean Society of Developmental Biology | Improved conditions for cryopreservation of human adipose tissue or umbilical cord derived mesenchymal stem cells |
| The 16th Annual Meeting American society of gene and cell therapy | Culture and cryopreservation of human epidermal melanocytes (MC) for preclinical trials |
on Regeneration of Stem cells (Ⅰ)▼
| The 5th International Society for Stem Cell Research | Regeneration potential of human adipose tissue-derived stem cells on cryo-induced injury of mouse thigh muscle |
|---|---|
| The 6th International Society for Stem Cell Research | Evaluation for cardiomyogenic regeneration of human CD34-positive adipose-derived stromal progenitor cells |
| The 16th International Society for Cell Therapy | Development for preclinical trial of human skin melanocyte progenitor cells |
| The 2nd TERMIS World Congress | Morphological study on the transplantation of human adipose-derived stem cells in a rabbit model of traumatic degeneration of lumbar disc |
| The 28th Annual Meeting of Korean Society of Developmental Biology | Therapeutic approach to the neurodegenerative diseases based on stem cell bank |
| The 17th International Society for Cell Therapy | A comparative study of effect of the oxygen microenvironment on in vitro the angiogenesis of human adipose tissue- or umbilical cord-derived stromal progenitor cells |
| The 29th Annual Meeting of Korean Society of Developmental Biology | Neuroprotective properties and neural differentiation of the human adipose tissue-derived mesenchymal stem cells transplanted in ischemic rat brain injury |
| The 29th Annual Meeting of Korean Society of Developmental Biology | Potential applications of human adipose derived stem cells |
| The 16th World Congress on In Vitro Fertilization | Improved conditions for cryopreservation of human adipose tissue or umbilical cord derived mesenchymal stem cells |
| The 32th Annual Meeting of Korean Society of Developmental Biology | Mesenchymal stem cells from aspirated adipose tissue can assist in ex vivo expansion of melanocytes for cell therapy |
| The 32th Annual Meeting of Korean Society of Developmental Biology | Preclinical examination of transplantation of human melanocytes and adipose-derived stromal cells for the treatment of vitiligo |
| The 16th Annual Meeting American society of gene and cell therapy | Qualification for human umbilical cord derived mesenchymal stem cells(hUC-MSCs) for regenerative medicine |
on Regeneration of Stem cells (Ⅱ)▼
| Mol Cells (2006) 21(3);343-355 | Profiling of differentially expressed genes in human stem cells by cDNA microarray |
|---|---|
| Neuroreport (2007) 18(11);35-38 | Estrogen simulates the neuronal differentiation of human umbilical cord blood mesenchymal stem cells (CD34-) |
| Cloning Stem Cells (2007) 9(4);581-594 | Ex vivo characteristics of human amniotic membrane-derived stem cells |
| Dev Reprod (2008) 12(1);31-39 | Differentiation of dopaminergic and cholinergic neurons form mesenchymal-like stem cells derived from the adipose tissue |
| Dev Reprod (2011) 15(2);99-111 | Chondrogenesis of human adipose tissue derived mesenchymal stem cells seeded in gelatin-chondroitin-glucosamine scaffold |
| World Neurosurgery (2012) 78(3); 364-371 | Transplantation of human adipose-derived stem cells in a rabbit model of traumatic degeneration of lumbar discs |
| Aesthetic Plast Surg (2013) 37(4);802-8 | Safety of adipose-derived stem cells and collagenase in fat tissue preparation |
| Mol Cells (2013) 36;534-541 | Administration of mesenchymal stem cells and ziprasidone enhanced amelioration of ischemic brain damage in rats |
| Animal Cell Systems (2013) 17(3);160-169 | Combination effect of p-hydroxybenzyl alcohol and mesenchymal stem cells on the recovery of brain damage in a rat model of brain ischemia |
| Tissue Cell (2014) 46;127-13 | Valproic acid promotes differentiation of hepatocyte-like cells from whole human umbilical cord-derived mesenchymal stem cells |
| Regulatory Toxicology and Pharmacology (2016) 81;437-447 | Human umbilical cord-derived mesenchymal stem cells in acute liver injury: Hepatoprotective efficacy, subchronic toxicity, tumorigenicity, and biodistribution |
| Gastroenterology (2017)152;1174–1186 | Milk fat globule-EGF factor 8, secreted by mesenchymal stem cells, protects against liver fibrosis in mice |